A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy

@article{Hayashi2006ACR,
  title={A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy},
  author={Masaaki Hayashi and Kyoko Imanaka-Yoshida and Toshimichi Yoshida and Malcolm R. Wood and Colleen Fearns and Revati J. Tatake and Jenq-kuen Lee},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={128-132}
}
Many heat-shock proteins (Hsp) are members of evolutionarily conserved families of chaperone proteins that inhibit the aggregation of unfolded polypeptides and refold denatured proteins, thereby remedying phenotypic effects that may result from protein aggregation or protein instability. Here we report that the mitochondrial chaperone Hsp40, also known as Dnaja3 or Tid1, is differentially expressed during cardiac development and pathological hypertrophy. Mice deficient in Dnaja3 developed… CONTINUE READING
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