A crucial role for hnRNP K in axon development in Xenopus laevis.

  title={A crucial role for hnRNP K in axon development in Xenopus laevis.},
  author={Yuanyuan Liu and Christine Gervasi and Ben G Szaro},
  volume={135 18},
We report that hnRNP K, an RNA-binding protein implicated in multiple aspects of post-transcriptional gene control, is essential for axon outgrowth in Xenopus. Its intracellular localization was found to be consistent with one of its known roles as an mRNA shuttling protein. In early embryos, it was primarily nuclear, whereas later it occupied both the nucleus and cytoplasm to varying degrees in different neuronal subtypes. Antisense hnRNP K morpholino oligonucleotides (MOs) microinjected into… CONTINUE READING


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