A crucial role for adipose tissue p53 in the regulation of insulin resistance

@article{Minamino2009ACR,
  title={A crucial role for adipose tissue p53 in the regulation of insulin resistance},
  author={Tohru Minamino and Masayuki Orimo and Ippei Shimizu and Takeshige Kunieda and Masataka Yokoyama and Takashi K. Ito and Aika Nojima and Akira Nabetani and Yuichi Oike and Hisahiro Matsubara and Fuyuki Ishikawa and Issei Komuro},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={1082-1087}
}
Various stimuli, such as telomere dysfunction and oxidative stress, can induce irreversible cell growth arrest, which is termed 'cellular senescence'. This response is controlled by tumor suppressor proteins such as p53 and pRb. There is also evidence that senescent cells promote changes related to aging or age-related diseases. Here we show that p53 expression in adipose tissue is crucially involved in the development of insulin resistance, which underlies age-related cardiovascular and… 
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