A crucial role for adipose tissue p53 in the regulation of insulin resistance

Abstract

Various stimuli, such as telomere dysfunction and oxidative stress, can induce irreversible cell growth arrest, which is termed 'cellular senescence'. This response is controlled by tumor suppressor proteins such as p53 and pRb. There is also evidence that senescent cells promote changes related to aging or age-related diseases. Here we show that p53… (More)
DOI: 10.1038/nm.2014

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