A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia

  title={A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia},
  author={Fabiana De Toni and Claire Racaud-Sultan and Ga{\"e}tan Chicanne and V{\'e}ronique Mansat-De Mas and Clotilde Cariven and Fabienne M{\'e}sange and Jean Pierre Salles and C Saura Demur and Mich{\`e}le Allouche and Bernard Payrastre and St{\'e}phane Manenti and Lo{\"i}c Ysebaert},
Relapses following chemotherapy are a major hindrance to patients’ survival in acute myeloid leukemia (AML). To investigate the role of the hematopoietic niche in the chemoresistance of leukemic cells, we examined two pathways: one mediated by adhesion molecules/integrins, and the other by soluble factors of the morphogen Wnt pathway. In our study, both the adhesion of leukemic blasts to fibronectin and the addition of Wnt antagonists induced, independently, resistance of AML cells to… CONTINUE READING


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