A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy.

@article{Weng2015ACB,
  title={A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy.},
  author={X. Weng and Liming Yu and P. Liang and Luyang Li and X. Dai and Bisheng Zhou and Xiaoyan Wu and H. Xu and M. Fang and Qi Chen and Y. Xu},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={82},
  pages={
          48-58
        }
}
  • X. Weng, Liming Yu, +8 authors Y. Xu
  • Published 2015
  • Biology, Medicine
  • Journal of molecular and cellular cardiology
Angiotensin II (Ang II) induces cardiac hypertrophy and fibrosis in part by stimulating endothelin (ET-1) transcription. The involvement of the epigenetic machinery in this process is largely undefined. In the present study, we examined the epigenetic maneuvering underlying cardiac hypertrophy and fibrosis following ET-1 transactivation by Ang II. In response to Ang II stimulation, core components of the mammalian chromatin remodeling complex (Brahma-related gene 1, or Brg1, and Brahma or Brm… Expand
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