A crossover comparison of progression of chronic renal failure: ketoacids versus amino acids.

@article{Walser1993ACC,
  title={A crossover comparison of progression of chronic renal failure: ketoacids versus amino acids.},
  author={Mackenzie Walser and S B Hill and L Ward and Laurence S. Magder},
  journal={Kidney international},
  year={1993},
  volume={43 4},
  pages={
          933-9
        }
}
Rates of progression of chronic renal failure were compared in patients receiving alternately an amino acid supplement (AA) and a ketoacid supplement (KA) to a very low protein (0.3 g/kg), low phosphorus (7 to 9 mg/kg) diet. The first supplement was randomly chosen. Bias due to carryover effects was minimized by delaying the regression analysis until one month after starting or changing supplements. In order to minimize possible bias caused by initiating the two supplements at differing levels… 
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TLDR
The results suggest that this ketoacid supplement slows progression by approximately half, compared with an essential amino acid supplement, with no change in diet.
Progression of chronic renal failure in patients given ketoacids following amino acids.
TLDR
This ketoacid supplemented regimen apparently halted the progression of moderately-severe chronic renal failure for at least a year in a small group of patients in whom restriction of protein and phosphate intake without ketoacids failed to halt progression.
The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure.
TLDR
This regimen with a low-phosphorus diet containing 20 to 30 g of mixed-quality protein, supplemented by amino acids and their keto analogues must have slowed or halted the progression of renal insufficiency in a majority of cases, especially when treatment was initiated before creatinine had reached the level of 8 mg per deciliter.
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The mechanisms by which the low-phosphorus, low-nitrogen diet slows the progression of renal failure are discussed, and the practical importance of prescribing the dietetic restriction early in the course of renal disease is stressed.
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TLDR
Progression of chronic renal failure during 35 treatment periods in 27 patients was measured as the rate of change of bimonthly radioisotope GFR for an average of 15 months, and additional significant regressors appeared: serum triglycerides and polycystic kidney disease and ketoacid treatment, which tended to be associated with more rapid progression.
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TLDR
There was a significant correlation between the change in progression rate and thechange in mean arterial pressure, a relationship which was also present in patients with mild hypertension or those with blood pressure within the "normal" range.
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TLDR
In the third group of uremics on repeated dialysis therapy, the deterioration of creatinine clearance was markedly accelerated and the possible explanations and the practical implications of these findings are discussed.
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TLDR
When KA were given after EAA, urea appearance fell and N balance improved, and when EAA were give after KA (5 studies), Urea appearance and N Balance did not worsen significantly during the 4-9 days of observation.
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TLDR
From the estimated total nitrogen excretion, dietary compliance of CRF patients in approximately neutral nitrogen balance could be assessed and nitrogen balance calculated using estimated U and 31 mg N/kg/day was indistinguishable statistically from measured nitrogen balance.
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TLDR
In conclusion, on the basis of these preliminary observations, the SD seems to exert several beneficial and no unwanted side-effects in renal failure of type I diabetics.
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