A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin.

@article{Chabanon2008ACB,
  title={A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin.},
  author={Aur{\'e}lie Chabanon and Christophe Desterke and Emilie Rodenburger and Denis Clay and Bernadette Guerton and Laetitia Boutin and Annelise Bennaceur-Griscelli and Olivier Pierre-Louis and Georges Uzan and Lucile Ab{\'e}cassis and M. Bourgeade and J. L. Lataillade and Marie-Caroline Le Bousse-Kerdil{\`e}s},
  journal={Stem cells},
  year={2008},
  volume={26 12},
  pages={
          3150-61
        }
}
Cell cycle regulation plays a fundamental role in stem cell biology. A balance between quiescence and proliferation of hematopoietic stem cells in interaction with the microenvironment is critical for sustaining long-term hematopoiesis and for protection against stress. We analyzed the molecular mechanisms by which stromal cell-derived factor-1 (SDF-1) exhibited a cell cycle-promoting effect and interacted with transforming growth factor-beta (TGF-beta), which has negative effects on cell cycle… CONTINUE READING
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