A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.

@article{Kwekel2005ACA,
  title={A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.},
  author={Joshua C. Kwekel and L. D. Burgoon and Jeremy W Burt and Jack R. Harkema and Timothy R. Zacharewski},
  journal={Physiological genomics},
  year={2005},
  volume={23 3},
  pages={327-42}
}
Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 153 orthologous gene pairs that were positively correlated, suggesting conserved transcriptional targets important in uterine proliferation. Functional annotation for these responses… CONTINUE READING