A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes

@article{Schnakenberg2007ACS,
  title={A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes},
  author={E. Schnakenberg and K. Fabig and M. Stanulla and Nils Strobl and M. Lustig and Nathalie Fabig and W. Schloot},
  journal={Environmental Health},
  year={2007},
  volume={6},
  pages={6 - 6}
}
BackgroundN-acetyltransferases (NAT) and glutathione S-transferases (GST) are involved in the metabolism of several ubiquitous chemical substances leading to the activation and detoxification of carcinogenic heterocyclic and aromatic amines. Since polymorphisms within these genes are described to influence the metabolism of ubiquitous chemicals, we conducted the present study to determine if individuals with self-reported chemical-related sensitivity differed from controls without self-reported… Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.
TLDR
A gene-gene interaction between CYP2D6 and NAT2 suggested that rapid metabolism for both enzymes may confer substantially elevated risk and this first demonstration of genetic variation in drug-metabolizing enzymes in association with MCS requires replication. Expand
Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1.
TLDR
The present data seem to suggest that apart from the methodology usually used for monitoring populations occupationally exposed to styrene the analysis of individual genotypes associated with the metabolic fate of styrene should also be carried out in order to evaluate the individual genetic susceptibility of exposed populations. Expand
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer.
TLDR
It is suggested that polymorphisms of CYP1A1, GSTM1, and NAT2 significantly affect either the frequency or the level of DNA adducts in normal breast tissues of women having breast cancer, especially in smokers. Expand
Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer.
TLDR
The data support the idea that in smokers who lack the GSTM1 gene, activation of carcinogens in tobacco smoke is increased, while the efficacy of detoxification is limited both qualitatively (absence of GSTm1-1 enzyme and low expression of GSTM3-3 enzyme) and quantitatively (low overall GST activity). Expand
Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity.
TLDR
The results suggest that GSTM1 homozygous null genotype may modify the effect of occupational sun exposure on the risk of SLE in caucasians. Expand
Gender‐specific effects of NAT2 and GSTM1 in bladder cancer
TLDR
In male patients, slow acetylators were identified as carrying a significant increased risk of developing bladder cancer, in particular when the genotype NAT2*5B/*6A was combined with the GSTM1 null genotype, and the same genotype combination significantly protected female patients from bladder cancer. Expand
Metabolic gene polymorphism frequencies in control populations.
  • S. Garte, L. Gaspari, +63 authors E. Taioli
  • Biology, Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2001
TLDR
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes in the human population were determined. Expand
Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.
  • H. Autrup
  • Biology, Medicine
  • Mutation research
  • 2000
TLDR
Additional studies on the role of genetic variants of xenobiotica metabolizing enzymes and combinations thereof at relevant low levels of exposure are important in order to establish guidance values for toxic compounds. Expand
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
TLDR
A novel PCR assay has been developed which demonstrates that these two variant cDNAs represent distinct GSTP 1 alleles (GSTP1a and GSTP1b), which are found to be strongly associated with bladder cancer and testicular cancer and in prostate cancer a highly significant decrease was observed. Expand
Relationship between metabolic enzyme polymorphism and colorectal cancer.
AIM To clarify the influence of genetic polymorphisms on colorectal cancer. METHODS The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effectExpand
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