A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity

@article{Corsonello2010ACA,
  title={A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity},
  author={A. Corsonello and A. Montesanto and M. Berardelli and F. De Rango and S. Dato and V. Mari and B. Mazzei and F. Lattanzio and G. Passarino},
  journal={Age and Ageing},
  year={2010},
  volume={39},
  pages={723 - 727}
}
  • A. Corsonello, A. Montesanto, +6 authors G. Passarino
  • Published 2010
  • Medicine
  • Age and Ageing
  • Background: several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may be detrimental. Objectives: to verify whether declining levels of circulating thyroid hormones may contribute to longevity. Design: cross-sectional observational study. Setting: all subjects were born in Calabria (southern Italy) and their ancestry in the region was ascertained up to the grandparents. Subjects: six hundred and four home… CONTINUE READING

    Tables and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Thyroid hormones as predictors of short- and long-term mortality in very old hospitalized patients.
    19
    Mild Thyroid Deficiency in the Elderly

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 27 REFERENCES
    Complex alteration of thyroid function in healthy centenarians.
    180
    Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study.
    57
    Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.
    112
    Hormones in 'young' and 'old' elderly: pituitary-thyroid and pituitary-adrenal axes.
    20
    Is there evidence for an age-related reduction in metabolic rate?
    143
    The clinical significance of subclinical thyroid dysfunction.
    997