A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity

@inproceedings{Corsonello2010ACA,
  title={A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity},
  author={Andrea Corsonello and Alberto Montesanto and Maurizio Berardelli and Francesco De Rango and Serena Dato and Vincenzo Mari and Bruno Mazzei and Fabrizia Lattanzio and Giuseppe Passarino},
  booktitle={Age and ageing},
  year={2010}
}
BACKGROUND several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may be detrimental. OBJECTIVES to verify whether declining levels of circulating thyroid hormones may contribute to longevity. DESIGN cross-sectional observational study. SETTING all subjects were born in Calabria (southern Italy) and their ancestry in the region was ascertained up to the grandparents. SUBJECTS six hundred and four… CONTINUE READING