Corpus ID: 22398951

A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and-81 expressed in cancer of blood group 0 or B individuals : Its identification as Tn antigen ( lung cancer / mucin / A-like antigen / a-N-acetylgalactosamine )

@inproceedings{Hirohashi2003ACE,
  title={A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and-81 expressed in cancer of blood group 0 or B individuals : Its identification as Tn antigen ( lung cancer / mucin / A-like antigen / a-N-acetylgalactosamine )},
  author={S. Hirohashi and H. Clausen and Tesshi YAMADAt and Yukio SHIMOSATOt and S. Hakomori},
  year={2003}
}
Two monoclonal antibodies, NCC-LU-35 and NCC-LU-81, have been established after immunization of mice with membrane preparations of human lung cancer Lu65 tumor xenograft cells grown in vivo and intact cells cultured in vitro, respectively. These two antibodies react specifically with a majority of human adenocarcinomas, irrespective of the host's blood group ABO status, as well as with normal tissues and erythrocytes ofblood group A individuals. The antigenicity is associated with a high… Expand

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