A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility

@article{Gupta2016ACS,
  title={A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility},
  author={Aditi Gupta and Garima Juyal and Ajit Sood and Vandana Midha and Keiko Yamazaki and Arnau Vich Vila and Motohiro Esaki and Toshiyuki Matsui and Atsushi Takahashi and Michiaki Kubo and Rinse Karel Weersma and B K Thelma},
  journal={European Journal of Human Genetics},
  year={2016},
  volume={25},
  pages={111-122}
}
The first ever genome-wide association study (GWAS) of ulcerative colitis in genetically distinct north Indian population identified two novel genes namely CFB and SLC44A4. Considering their biological relevance, we investigated allelic/genetic heterogeneity in these genes among ulcerative colitis cohorts of north Indian, Japanese and Dutch origin using high-density ImmunoChip case–control genotype data. Comparative linkage disequilibrium profiling and test of association were performed. Of the… CONTINUE READING
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