A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients

@inproceedings{Chatterjee2015ACC,
  title={A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients},
  author={Aniruddha Chatterjee and Anna L. Leichter and Vicky Fan and Peter Tsai and Rachel V Purcell and Michael J Sullivan and M R Eccles},
  booktitle={Scientific reports},
  year={2015}
}
Although formalin fixed paraffin embedded (FFPE) tissue is a major biological source in cancer research, it is challenging to work with due to macromolecular fragmentation and nucleic acid crosslinking. Therefore, it is important to characterise the quality of data that can be obtained from FFPE samples. We have compared three independent platforms (next generation sequencing, microarray and NanoString) for profiling microRNAs (miRNAs) using clinical FFPE samples from hepatoblastoma (HB… CONTINUE READING
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