A critique of the double-blind clinical trial. Part 2.

@article{Kiene1996ACO,
  title={A critique of the double-blind clinical trial. Part 2.},
  author={Helmm Kiene},
  journal={Alternative therapies in health and medicine},
  year={1996},
  volume={2 2},
  pages={59-64}
}
  • Helmm Kiene
  • Published 1996 in Alternative therapies in health and medicine
The randomized, double-blind study is generally regarded as the gold standard of clinical drug trials. Bias can occur as a result of the blinding procedure itself, but discussions of this type of bias have been few and far between. This article continues with a detailed discussion of such blinding errors, which can obscure genuine drug effects and be of a sufficient magnitude as to generate false-negative results. Uncritical blinding in clinical studies should therefore be questioned. 

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