A critical view of coronary reserve.

  title={A critical view of coronary reserve.},
  author={Julien I E Hoffman},
  volume={75 1 Pt 2},
Coronary flow reserve is reduced by pathologic acquired left ventricular hypertrophy, and is less in subendocardial than subepicardial layers of normal or hypertrophied hearts. In normal hearts, pacing-induced tachycardia at a rate of 250 beats/min does not alter coronary reserve in the outer half of the left ventricular wall. Pacing produces a linear decrease in coronary reserve in the inner half, although the decrease is attenuated if perfusion pressure is elevated, as in systemic… CONTINUE READING