A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.

@article{Kim2004ACS,
  title={A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.},
  author={I. J. Kim and C. Dersch and R. Rothman and A. E. Jacobson and K. Rice},
  journal={Bioorganic \& medicinal chemistry},
  year={2004},
  volume={12 16},
  pages={
          4543-50
        }
}
The opioid receptor binding affinities of N-methyl- and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the affinities of four new ligands bearing an ortho- or para-hydroxyl substituent (2-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (2a) and 2-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (2b), 4-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol… Expand
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