A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression.

@article{Calabresi1999ACR,
  title={A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression.},
  author={Paolo Calabresi and Paolo Gubellini and Diego Centonze and Giuseppe Sancesario and Maria Morello and Mauro Giorgi and Antonio Pisani and Giorgio Bernardi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 7},
  pages={2489-99}
}
High-frequency stimulation (HFS) of corticostriatal glutamatergic fibers induces long-term depression (LTD) of excitatory synaptic potentials recorded from striatal spiny neurons. This form of LTD can be mimicked by zaprinast, a selective inhibitor of cGMP phosphodiesterases (PDEs). Biochemical analysis shows that most of the striatal cGMP PDE activity is calmodulin-dependent and inhibited by zaprinast. The zaprinast-induced LTD occludes further depression by tetanic stimulation and vice versa… CONTINUE READING
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