A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory.

@article{Mothet2006ACR,
  title={A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory.},
  author={J P Mothet and E. Rouaud and P-M Sinet and Brigitte Potier and Anne Jouvenceau and Patrick Dutar and Catherine Videau and Jacques Epelbaum and J. M. Billard},
  journal={Aging cell},
  year={2006},
  volume={5 3},
  pages={267-74}
}
Age-associated deficits in learning and memory are closely correlated with impairments of synaptic plasticity. Analysis of N-methyl-D-aspartate receptor (NMDAr)-dependent long-term potentiation (LTP) in CA1 hippocampal slices indicates that the glial-derived neuromodulator D-serine is required for the induction of synaptic plasticity. During aging, the content of D-serine and the expression of its synthesizing enzyme serine racemase are significantly decreased in the hippocampus. Impaired LTP… CONTINUE READING

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