A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development

Abstract

CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previously been emphasised in the aetiology of… (More)
DOI: 10.1016/j.ydbio.2015.06.017

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