A critical role for noncoding 5S rRNA in regulating Mdmx stability.

@article{Li2011ACR,
  title={A critical role for noncoding 5S rRNA in regulating Mdmx stability.},
  author={Muyang Li and Wei Gu},
  journal={Molecular cell},
  year={2011},
  volume={43 6},
  pages={1023-32}
}
Both p53 and Mdmx are ubiquitinated and degraded by the same E3 ligase Mdm2; interestingly, however, while p53 is rapidly degraded by Mdm2, Mdmx is a stable protein in most cancer cells. Thus, the mechanism by which Mdmx is degraded by Mdm2 needs further elucidation. Here, we identified the noncoding 5S rRNA as a major component of Mdmx-associated complexes… CONTINUE READING