A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers.

@article{Planz1997ACR,
  title={A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers.},
  author={Oliver Planz and Stephan Ehl and Esther Furrer and Edit Horvath and Marie Anne Br{\"u}ndler and Hans Hengartner and Roll M. Zinkernagel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 13},
  pages={6874-9}
}
This study demonstrates that neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons (IFNs) are of key importance in virus control both in adoptive immunotherapy of persistent infection and in the late phase of acute infection with the WE strain of lymphocytic choriomeningitis virus (LCMV). We report the following results. (i) Clearance of LCMV-WE from C57BL/6 carrier mice by adoptive transfer of memory spleen cells requires B cells and CD4(+) T cells but not necessarily CD8… CONTINUE READING
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Planz et al

  • R. M. Zinkernagel, M. F. Bachmann, +5 authors 333–372. Immunology
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

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