A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death.

  title={A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death.},
  author={Nica M. Borradaile and Kimberly K. Buhman and Laura L. Listenberger and Carolyn J Magee and Emiko T A Morimoto and Daniel S Ory and Jean E Schaffer},
  journal={Molecular biology of the cell},
  volume={17 2},
The deleterious consequences of fatty acid (FA) and neutral lipid accumulation in nonadipose tissues, such as the heart, contribute to the pathogenesis of type 2 diabetes. To elucidate mechanisms of FA-induced cell death, or lipotoxicity, we generated Chinese hamster ovary (CHO) cell mutants resistant to palmitate-induced death and isolated a clone with disruption of eukaryotic elongation factor (eEF) 1A-1. eEF1A-1 involvement in lipotoxicity was confirmed in H9c2 cardiomyoblasts, in which… CONTINUE READING


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