A critical role for eosinophils in allergic airways remodeling.

@article{Humbles2004ACR,
  title={A critical role for eosinophils in allergic airways remodeling.},
  author={Alison A Humbles and Clare M. Lloyd and Sarah J. McMillan and Daniel S. Friend and Georgina Xanthou and Erin E McKenna and Sorina Ghiran and Norma P. Gerard and Channing Yu and Stuart H Orkin and Craig Gerard},
  journal={Science},
  year={2004},
  volume={305 5691},
  pages={
          1776-9
        }
}
Features of chronic asthma include airway hyperresponsiveness, inflammatory infiltrates, and structural changes in the airways, termed remodeling. The contribution of eosinophils, cells associated with asthma and allergy, remains to be established. We show that in mice with a total ablation of the eosinophil lineage, increases in airway hyperresponsiveness and mucus secretion were similar to those observed in wild-type mice, but eosinophil-deficient mice were significantly protected from… CONTINUE READING

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