A critical role for endocytosis in Wnt signaling

  title={A critical role for endocytosis in Wnt signaling},
  author={Jeremy T. Blitzer and Roeland Nusse},
  journal={BMC Cell Biology},
  pages={28 - 28}
The Wnt signaling pathway regulates many processes during embryonic development, including axis specification, organogenesis, angiogenesis, and stem cell proliferation. Wnt signaling has also been implicated in a number of cancers, bone density maintenance, and neurological conditions during adulthood. While numerous Wnts, their cognate receptors of the Frizzled and Arrow/LRP5/6 families and downstream pathway components have been identified, little is known about the initial events occurring… CONTINUE READING