A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

@article{Kim2007ACR,
  title={A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity},
  author={Tae Whan Kim and Kirk A. Staschke and Katarzyna Bulek and Jianhong Yao and Kristi Peters and K Oh and Yvonne Vandenburg and Hui Xiao and Wen Qian and Tom Hamilton and Booki Min and Ganes Sen and Raymond Gilmour and Xiaoxia Li},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={1025 - 1036}
}
IRAK4 is a member of IL-1 receptor (IL-1R)-associated kinase (IRAK) family and has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. We recently generated IRAK4 kinase-inactive knock-in mice to examine the role of kinase activity of IRAK4 in TLR-mediated signaling pathways. The IRAK4 kinase-inactive knock-in mice were completely resistant to lipopolysaccharide (LPS)- and CpG-induced shock, due to impaired TLR-mediated induction of proinflammatory cytokines and… CONTINUE READING

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