A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.

@article{Bubier2009ACR,
  title={A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.},
  author={Jason A. Bubier and Thomas J. Sproule and Oded Foreman and Rosanne Spolski and Daniel J. Shaffer and Herbert C. Morse and Warren J Leonard and Derry Charles Roopenian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 5},
  pages={1518-23}
}
Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that affects the differentiation and function of T, B, and NK cells by binding to a receptor consisting of the common cytokine receptor gamma chain and the IL-21 receptor (IL-21R). IL-21, a product associated with IL-17-producing CD4 T cells (T(H)17) and follicular CD4 T helper cells (T(FH)), has been implicated in autoimmune disorders including the severe systemic lupus erythematosus (SLE)-like disease characteristic of… CONTINUE READING