A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis

@article{Wilson2005ACR,
  title={A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis},
  author={Emma H Wilson and Ulrike Wille-Reece and Florence S Dzierszinski and Christopher A Hunter},
  journal={Journal of Neuroimmunology},
  year={2005},
  volume={165},
  pages={63-74}
}
IL-10 plays a vital role in controlling the inflammatory response during acute Toxoplasma gondii infection, however the production of IL-10 during the chronic phase of toxoplasmosis has been associated with parasite persistence. To address this paradox, the production and effect of IL-10 in the brain during toxoplasmic encephalitis (TE) was investigated. Analysis of brain mononuclear cells (BMNC) from chronically infected mice revealed that infiltrating macrophages and CD4(+) T cells were the… CONTINUE READING

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