A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

@inproceedings{Fisher2017ACR,
  title={A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism},
  author={Ffolliott Martin Fisher and Misung Kim and Ludivine Doridot and Jeremy C. Cunniff and Thomas S. Parker and Dr. Gertrude Levine and Marc K. Hellerstein and Lisa Cooper Hudgins and Eleftheria Maratos-Flier and M. A. Syamsul Herman},
  booktitle={Molecular metabolism},
  year={2017}
}
OBJECTIVE Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that the metabolic hormone FGF21 is regulated by fructose consumption in humans and rodents and may play a functional role in this nutritional context. Here, we sought to define the mechanism by which fructose ingestion regulates FGF21 and determine whether FGF21 contributes to an adaptive metabolic response to fructose consumption… CONTINUE READING
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