A critical role for CCR 2 / MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation

@inproceedings{Hildebrandt2004ACR,
  title={A critical role for CCR 2 / MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation},
  author={Gerhard C. Hildebrandt and Ulrich A. Duffner and Krystyna M. Olkiewicz and Leigh A. Corrion and Nicole E. Willmarth and Debra L. Williams and Shawn G. Clouthier and Cory M Hogaboam and P. Rakeshkumar Reddy and Bethany B Moore and William A. Kuziel and Chen Liu and Gregory Anthony Yanik and Kenneth R. Cooke},
  year={2004}
}
Idiopathic pneumonia syndrome (IPS) is a major complication after allogeneic bone marrow transplantation (allo-BMT) and involves the infiltration of donor leukocytes and the secretion of inflammatory cytokines. We hypothesized that leukocyte recruitment during IPS is dependent in part upon interactions between chemokine receptor 2 (CCR2) and its primary ligand monocyte chemoattractant protein–1 (MCP-1). To test this hypothesis, IPS was induced in a lethally irradiated parent3 F1 mouse BMT model… CONTINUE READING

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