A critical review on the clinical pharmacokinetics, pharmacodynamics, and clinical trials of ceftaroline.

Abstract

Only a parenteral formulation of ceftaroline is commercially available, and the prodrug, ceftaroline fosamil, is hydrolyzed quickly and completely upon intravenous administration. Ceftaroline is relatively minimally bound to plasma proteins (15-28 %), with a volume of distribution of 30-40 L. Ceftaroline undergoes minimal metabolism and does not appear to… (More)
DOI: 10.1007/s40262-015-0281-3

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