A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.
@article{Zuardi2012ACR, title={A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.}, author={A. W. Zuardi and J. Crippa and J. Hallak and S. Bhattacharyya and Z. Atakan and R. Martin-Santos and P. McGuire and F. Guimar{\~a}es}, journal={Current pharmaceutical design}, year={2012}, volume={18 32}, pages={ 5131-40 } }
Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is the main compound of the Cannabis Sativa responsible for most of the effects of the plant. Another major constituent is cannabidiol (CBD), formerly regarded to be devoid of pharmacological activity. However, laboratory rodents and human studies have shown that this cannabinoid is able to prevent psychotic-like symptoms induced by high doses of Δ(9)- THC. Subsequent studies have demonstrated that CBD has antipsychotic effects as observed using animal… CONTINUE READING
Paper Mentions
News Article
143 Citations
A systematic review of the antipsychotic properties of cannabidiol in humans
- Psychology, Medicine
- Schizophrenia Research
- 2015
- 150
- PDF
The development of Cannabidiol as a psychiatric therapeutic: a review of its antipsychotic efficacy and possible underlying pharmacodynamic mechanisms
- Psychology
- 2013
- 1
- Highly Influenced
- PDF
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
- Medicine
- Front. Immunol.
- 2018
- 69
- PDF
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
- Medicine
- Philosophical Transactions of the Royal Society B: Biological Sciences
- 2012
- 224
- PDF
Could cannabidiol be used as an alternative to antipsychotics?
- Psychology, Medicine
- Journal of psychiatric research
- 2016
- 20
- PDF
Cannabidiol as a potential treatment for psychosis
- Medicine
- Therapeutic advances in psychopharmacology
- 2019
- 15
- PDF
Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?
- Medicine
- Journal of epilepsy research
- 2017
- 99
- PDF
Peripubertal treatment with cannabidiol prevents the emergence of psychosis in an animal model of schizophrenia
- Medicine
- Schizophrenia Research
- 2016
- 21
Preclinical and Clinical Evidence Supporting Use of Cannabidiol in Psychiatry
- Medicine
- Evidence-based complementary and alternative medicine : eCAM
- 2019
- 3
- PDF
References
SHOWING 1-10 OF 86 REFERENCES
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.
- Medicine
- Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
- 2006
- 343
- PDF
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.
- Psychology, Medicine
- Revista brasileira de psiquiatria
- 2008
- 294
- PDF
[Therapeutical use of the cannabinoids in psychiatry].
- Medicine, Psychology
- Revista brasileira de psiquiatria
- 2010
- 59
- PDF
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
- Medicine
- Trends in pharmacological sciences
- 2009
- 544
- PDF
Safety and side effects of cannabidiol, a Cannabis sativa constituent.
- Medicine
- Current drug safety
- 2011
- 266
- PDF
Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia
- Psychology, Medicine
- Behavioural Brain Research
- 2011
- 63
Cannabidiol monotherapy for treatment-resistant schizophrenia
- Psychology, Medicine
- Journal of psychopharmacology
- 2006
- 144
Effects of cannabidiol in animal models predictive of antipsychotic activity
- Psychology, Medicine
- Psychopharmacology
- 2005
- 150
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
- Psychology, Medicine
- Translational Psychiatry
- 2012
- 565
- Highly Influential
- PDF
The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning.
- Psychology, Medicine
- Psychological medicine
- 2009
- 242