A critical review of neonicotinoid insecticides for developmental neurotoxicity

@inproceedings{Sheets2016ACR,
  title={A critical review of neonicotinoid insecticides for developmental neurotoxicity},
  author={Larry P. Sheets and Abby A. Li and Daniel J. Minnema and Richard H. Collier and Moire R. Creek and Richard C. Peffer},
  booktitle={Critical reviews in toxicology},
  year={2016}
}
A comprehensive review of published and previously unpublished studies was performed to evaluate the neonicotinoid insecticides for evidence of developmental neurotoxicity (DNT). These insecticides have favorable safety profiles, due to their preferential affinity for nicotinic receptor (nAChR) subtypes in insects, poor penetration of the mammalian blood-brain barrier, and low application rates. Nevertheless, examination of this issue is warranted, due to their insecticidal mode of action and… CONTINUE READING

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