A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes

@article{Kingery1997ACR,
  title={A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes},
  author={Wade S. Kingery},
  journal={Pain},
  year={1997},
  volume={73},
  pages={123-139}
}
  • W. Kingery
  • Published 1 November 1997
  • Medicine, Psychology
  • Pain
Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society.
TLDR
Randomized, controlled trials, systematic reviews and existing guidelines focusing on the pharmacological management of NeP were evaluated at a consensus meeting and recommendations for treatment are based on degree of evidence of analgesic efficacy, safety, ease of use and cost-effectiveness.
EFNS guidelines on pharmacological treatment of neuropathic pain
TLDR
Evaluated trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine and the newer antidepressants venlafaxine and duloxetine.
Defining the Therapeutic Role of Local Anesthetic Sympathetic Blockade in Complex Regional Pain Syndrome: A Narrative and Systematic Review
TLDR
This review raises questions as to the efficacy of local anesthetic sympathetic blockade as treatment of CRPS, based mainly on case series, which leads to an overestimation of the treatment response.
Pharmacologic management of neuropathic pain.
  • D. Gordon, G. Love
  • Medicine, Biology
    Pain management nursing : official journal of the American Society of Pain Management Nurses
  • 2004
Pharmacotherapy of complex regional pain syndrome.
  • R. Harden
  • Medicine, Psychology
    American journal of physical medicine & rehabilitation
  • 2005
TLDR
An overview of available data regarding drug and interventional treatment options for complex regional pain syndrome and of those relevant pharmacotherapies the authors can derive from the neuropathy literature is presented.
Pharmacologic Management of Complex Regional Pain Syndrome
TLDR
Treatment of CRPS has received insufficient study and remains largely empirical, so the relative benefit of oral medications compared with the widely used treatments of intensive physical therapy, nerve blocks, sympathectomy, intraspinally administered drugs, and neuromodulatory therapies remains uncertain.
Emerging therapies for neuropathic pain
TLDR
This update will review existing treatment options for neuropathic pain, and highlight more recent advances in the development of novel analgesics to treat this chronic disorder.
Intravenous infusion of phenytoin relieves neuropathic pain: a randomized, double-blinded, placebo-controlled, crossover study.
TLDR
It is concluded that IV infusion of 15 mg/kg pheny toin has an analgesic effect in acute flare-ups of neuropathic pain and that this relief outlives both the infusion time and plasma half-life of phenytoin.
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