A critical review of chronic stress effects on spatial learning and memory

  title={A critical review of chronic stress effects on spatial learning and memory},
  author={Cheryl D. Conrad},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • C. Conrad
  • Published 30 June 2010
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Converging effects of acute stress on spatial and recognition memory in rodents: A review of recent behavioural and pharmacological findings

Chronic restraint stress impairs sociability butnot social recognition and spatial memoryin C57BL/6J mice

It is confirmed that chronic stress produced no significant impairment in spatial learning and memory of the mice in the water maze and the modified protocol of the three-chamber paradigm observed that the stressed group had impairments in their sociability behaviour but that social recognition was not affected.

Sex differences in chronic stress effects on cognition in rodents

Recovery after chronic stress within spatial reference and working memory domains: correspondence with hippocampal morphology

The results indicate that chronic stress‐induced spatial working and reference memory impairments, and CA3 dendritic retraction, are reversible, with chronic stress having lasting effects that can benefit spatial reference memory, but with these lasting beneficial effects being independent of CA3dendritic complexity.

Sex-dependent effects of chronic unpredictable stress in the water maze

376 Effects of Restraint Stress and Nitric Oxide Synthase Inhibition on Learning and Strategy Preference in Young Adult Male Rats

This work has shown that place learning in the Water Maze is a frequently used cognitive test which can be applied with various modifications and NOS inhibition produces impairment in spatial learning and reduces performance in memory tasks.



Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.

Results from Experiment 4 showed that chronic restraint stress impaired spatial memory performance on the Y maze when rats were tested the day after the last stress session and that tianeptine prevented the stress-induced spatial memory impairment.

Stress and Memory: Behavioral Effects and Neurobiological Mechanisms

High stress levels, whether intrinsic or extrinsic, tend to facilitate Pavlovian conditioning (in a linear-asymptotic manner), while being deleterious for spatial/explicit information processing (which with regard to intrinsic stress levels follows an inverted U-shape effect).

SHORT COMMUNICATION Selective enhancement of spatial learning under chronic psychosocial stress

It is shown that chronic stress enhanced learning in animals performing the hippocampal‐dependent task, whereas no stress‐induced effect was found in the hippocampa‐independent task, and after five weeks of stress, cell proliferation was reduced in the hippocampusal dentate gyrus.

Stress‐Induced Changes in Spatial Memory are Sexually Differentiated and Vary Across the Lifespan

  • R. Bowman
  • Psychology, Biology
    Journal of neuroendocrinology
  • 2005
Sex differences in response to stress on a variety of spatial tasks are reviewed, highlighting the point that many effects obtained in males cannot be generalised to females and highlighting the need to investigate the stress response at different ages and in both sexes.