A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features

@article{Juliano2004ACR,
  title={A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features},
  author={Laura M Juliano and Roland R Griffiths},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={1-29}
}
RationaleAlthough reports of caffeine withdrawal in the medical literature date back more than 170 years, the most rigorous experimental investigations of the phenomenon have been conducted only recently.ObjectivesThe purpose of this paper is to provide a comprehensive review and analysis of the literature regarding human caffeine withdrawal to empirically validate specific symptoms and signs, and to appraise important features of the syndrome.MethodsA literature search identified 57… Expand
Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors.
TLDR
With the exception of nausea/upset stomach, the CWSQ total score and individual composite scores were significantly greater during caffeine abstinence relative to both baseline and double-blind consumption of caffeinated coffee, thereby demonstrating sensitivity of the measure. Expand
Fourteen well-described caffeine withdrawal symptoms factor into three clusters
RationaleAbrupt cessation of caffeine often results in several withdrawal symptoms among habitual caffeine consumers.ObjectiveThe objective of the study was to determine whether caffeine withdrawalExpand
Caffeine Withdrawal and Dependence: A Convenience Survey Among Addiction Professionals.
TLDR
The majority of addiction professionals believe that caffeine withdrawal and dependence disorders exist and are clinically important; however, these professionals are divided in whether caffeine withdrawals and dependence should be included in the Diagnostic and Statistical Manual of Mental Disorders. Expand
Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal
TLDR
It was found that researchers have generally failed to take account of the fact that habitual use of caffeine leads to physical dependence evidenced by physiological, behavioural and subjective withdrawal effects during periods of abstinence, and there has been near‐complete absence of adequate methodological controls against confounding due to reversal of withdrawal effects when caffeine is experimentally administered. Expand
Caffeine Use Disorder: A Comprehensive Review and Research Agenda.
Caffeine is the most commonly used drug in the world. Although consumption of low to moderate doses of caffeine is generally safe, an increasing number of clinical studies are showing that someExpand
A comparison of the effects of caffeine following abstinence and normal caffeine use
TLDR
Improvements in mood and reaction time may best be explained as relief from withdrawal symptoms, but other performance measures showed no evidence of withdrawal and were equally sensitive to an acute dose of caffeine in the normal caffeinated state. Expand
Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation
TLDR
Appropriately controlled studies show that the effects of caffeine on performance and mood, widely perceived to be net beneficial psychostimulant effects, are almost wholly attributable to reversal of adverse withdrawal effects associated with short periods of abstinence from the drug. Expand
Caffeine-withdrawal headache induced by hemodialysis
TLDR
A case of patient on hemodialysis (HD) with caffeine-withdrawal headache is reported, and the obligatory criterion is the improvement or resolution of headache after relief from the causative disorder. Expand
Medical students' use of caffeine for ‘academic purposes’ and their knowledge of its benefits, side-effects and withdrawal symptoms
TLDR
The high percentage of caffeine usage and low scores in the caffeine knowledge test indicated that most participants were using caffeine without having sufficient knowledge of its benefits, side-effects and withdrawal symptoms. Expand
Craving espresso: the dialetics in classifying caffeine as an abuse drug
TLDR
The diagnostic criteria evidenced on DSM-V to intoxication-continued use and abstinence are not well supported by clinical studies, and caffeine only partially fits its mechanism of action as an abuse drug. Expand
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