A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features

@article{Juliano2004ACR,
  title={A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features},
  author={L. M. Juliano and R. Griffiths},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={1-29}
}
  • L. M. Juliano, R. Griffiths
  • Published 2004
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleAlthough reports of caffeine withdrawal in the medical literature date back more than 170 years, the most rigorous experimental investigations of the phenomenon have been conducted only recently.ObjectivesThe purpose of this paper is to provide a comprehensive review and analysis of the literature regarding human caffeine withdrawal to empirically validate specific symptoms and signs, and to appraise important features of the syndrome.MethodsA literature search identified 57… CONTINUE READING
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