A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation

  title={A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation},
  author={G. De Palo and Darvin Yi and R. G. Endres},
  journal={PLoS Biology},
The transition from single-cell to multicellular behavior is important in early development but rarely studied. The starvation-induced aggregation of the social amoeba Dictyostelium discoideum into a multicellular slug is known to result from single-cell chemotaxis towards emitted pulses of cyclic adenosine monophosphate (cAMP). However, how exactly do transient, short-range chemical gradients lead to coherent collective movement at a macroscopic scale? Here, we developed a multiscale model… Expand

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  • E. Palsson, H. Othmer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000
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