A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages.

@article{Zhou2010ACF,
  title={A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages.},
  author={Yu Zhou and Xu Wang and Manqing Liu and Quan Hu and Li Song and Li Yun Ye and Dunjin Zhou and Wen-zhe Ho},
  journal={Immunology},
  year={2010},
  volume={131 1},
  pages={40-9}
}
Toll-like receptor-3 (TLR-3) recognizes double-stranded RNA and induces multiple intracellular events responsible for innate anti-viral immunity against a number of viral infections. Activation of TLR-3 inhibits human immunodeficiency virus (HIV) replication, but the mechanism(s) underlying the action of TLR-3 activation on HIV are largely unknown. Here we demonstrate that treatment of monocyte-derived macrophages with poly I:C, a synthetic ligand for TLR-3, significantly inhibited HIV… CONTINUE READING

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