A critical function for type I interferons in cancer immunoediting

@article{Dunn2005ACF,
  title={A critical function for type I interferons in cancer immunoediting},
  author={Gavin P. Dunn and Allen T. Bruce and Kathleen C.F. Sheehan and Vijay Shankaran and Ravindra Uppaluri and Jack D. Bui and Mark S. Diamond and Catherine M. Koebel and Cora D. Arthur and J Michael White and Robert D. Schreiber},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={722-729}
}
'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-γ (IFN-γ) is known to be involved in this process, the involvement of type I interferons (IFN-α/β) has not been elucidated. We now show that, like IFN-γ, endogenously produced IFN-α/β was required for the prevention of the growth of primary carcinogen–induced and transplantable tumors. Although tumor cells are… Expand
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