A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity.

@article{Astashkina2012ACE,
  title={A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity.},
  author={Anna I Astashkina and Brenda K. Mann and David William Grainger},
  journal={Pharmacology & therapeutics},
  year={2012},
  volume={134 1},
  pages={82-106}
}
Drug candidate and toxicity screening processes currently rely on results from early-stage in vitro cell-based assays expected to faithfully represent essential aspects of in vivo pharmacology and toxicology. Several in vitro designs are optimized for high throughput to benefit screening efficiencies, allowing the entire libraries of potential pharmacologically relevant or possible toxin molecules to be screened for different types of cell signals relevant to tissue damage or to therapeutic… CONTINUE READING
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