A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro.

@article{Schuler1997ACE,
  title={A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro.},
  author={Maik J Schuler and D. S. Rupa and David A. Eastmond},
  journal={Mutation research},
  year={1997},
  volume={392 1-2},
  pages={
          81-95
        }
}
The in vitro micronucleus assay in conjunction with CREST-staining and fluorescence in situ hybridization (FISH) with centromere-specific DNA probes is being increasingly utilized for the detection of clastogenic and aneuploidy-inducing agents. Although potentially powerful techniques, both methods have unique characteristics that can influence sample processing and the interpretation of results. In this article, the use of the CREST and the FISH modifications of the in vitro micronucleus assay… CONTINUE READING

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