A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function

Abstract

k-turns are commonly-occurring motifs that introduce sharp kinks into duplex RNA, thereby facilitating tertiary contacts. Both the folding and conformation of k-turns are determined by their local sequence. k-turns fall into two conformational classes, called N3 and N1, that differ in the pattern of hydrogen bonding in the core. We show here that this is… (More)
DOI: 10.1093/nar/gkw201

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