A critical assessment of topologically associating domain prediction tools

  title={A critical assessment of topologically associating domain prediction tools},
  author={Rola Dali and Mathieu Blanchette},
  booktitle={Nucleic acids research},
Topologically associating domains (TADs) have been proposed to be the basic unit of chromosome folding and have been shown to play key roles in genome organization and gene regulation. Several different tools are available for TAD prediction, but their properties have never been thoroughly assessed. In this manuscript, we compare the output of seven different TAD prediction tools on two published Hi-C data sets. TAD predictions varied greatly between tools in number, size distribution and other… CONTINUE READING
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