A critical appraisal of statistical pitfalls and clinical relevance of meta-analysis involving hepatitis C virus and sofosbuvir


Recently, Yang et al. [1] published a meta-analysis about sofosbuvir (SFV) and hepatitis c virus (HCV). One issue that was not emphasized is that HCV trials lack direct comparison between different treatments. In addition, clinical effects of these antivirals are clearly advantageous, until other evidences prove that long-term efficacy and toxicity provide… (More)
DOI: 10.1007/s11096-015-0192-2