A critical appraisal of "chronic Lyme disease".

  title={A critical appraisal of "chronic Lyme disease".},
  author={Henry M. Feder and Barbara J. B. Johnson and S. O'connell and Eugene D Shapiro and Allen C. Steere and Gary P. Wormser and William A. Agger and Harvey Artsob and Paul G. Auwaerter and J Stephen Dumler and Johan S. Bakken and Linda K Bockenstedt and J Green and Raymond J. Dattwyler and Jose Munoz and Robert B. Nadelman and Ira B. Schwartz and Thomas A. Draper and Edward Mcsweegan and John J Halperin and Mark S. Klempner and Peter J Krause and Paul S Mead and M G Morshed and Richard Porwancher and Justin D. Radolf and R. P. Smith and Sunil K. Sood and Arthur Weinstein and S. J. Wong and Lawrence S. Zemel},
  journal={The New England journal of medicine},
  volume={357 14},
“Chronic Lyme disease” is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease. 

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