A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley.

@article{Karamat2014ACP,
  title={A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley.},
  author={Fazeelat Karamat and Alexandre Olry and Ryosuke Munakata and Takao Koeduka and Akifumi Sugiyama and C{\'e}dric Paris and Alain Hehn and Fr{\'e}d{\'e}ric Bourgaud and Kazufumi Yazaki},
  journal={The Plant journal : for cell and molecular biology},
  year={2014},
  volume={77 4},
  pages={
          627-38
        }
}
Furanocoumarins constitute a sub-family of coumarin compounds with important defense properties against pathogens and insects, as well as allelopathic functions in plants. Furanocoumarins are divided into two sub-groups according to the alignment of the furan ring with the lactone structure: linear psoralen and angular angelicin derivatives. Determination of furanocoumarin type is based on the prenylation position of the common precursor of all furanocoumarins, umbelliferone, at C6 or C8, which… Expand
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The overexpression of CYP98A22 positively impacts the concentration of furanocoumarins in R. graveolens and is therefore a valuable tool to engineer plants with improved therapeutical values that might also be more resistant to phytophageous insects. Expand
Characterization of Coumarin-Specific Prenyltransferase Activities in Citrus limon Peel
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This study detected both O- and C-prenyltransferase activities of coumarin substrates in a microsome fraction prepared from lemon (Citrus limon) peel, where large amounts of prenylated coumarins accumulate, and provides information towards the discovery of a yet unidentified cou marin-specific prenytransferase gene. Expand
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Two novel genes coding for membrane-bound flavonoid prenyltransferases from S. flavescens are isolated and analysis on the substrate specificity of chimeric enzymes between SfN8DT-1 and SfG6DT suggested that the determinant region for the specificity of the flavonoids was the domain neighboring the fifth transmembrane α-helix of the prenytransferases. Expand
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TLDR
It is shown that the furanocoumarin-metabolic activity of CYP6B proteins in two species of swallowtail caterpillars is associated with the probability of encountering host plant furanOCoumarins, and Reconstruction of the ancestral CYP 6B sequences indicate that host plant diversity is directly related to P450 activity and inversely related to substrate specificity. Expand
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