A cost-effective screening test for detecting AZF microdeletions on the human Y chromosome.

@article{Pieri2002ACS,
  title={A cost-effective screening test for detecting AZF microdeletions on the human Y chromosome.},
  author={Patr{\'i}cia de Campos Pieri and Dirceu H Pereira and Sidney Glina and Jorge Hallak and Ken Mcelreavey and Carlos Alberto Moreira-Filho},
  journal={Genetic testing},
  year={2002},
  volume={6 3},
  pages={185-94}
}
PCR-based screening of microdeletions in the azoospermic factor (AZF) on the Yq chromosome is an accepted means of identifying a common genetic cause of male infertility, responsible for 5-15% of cases associated with a low sperm count (</=5 x 10(6) sptz/ml). Based on an extensive analysis of the literature, we have established a cost-effective preliminary PCR-based diagnostic screening test, with a set of six pairs of primers ("set-of-6") that have the capability of detecting up to 95% of the… CONTINUE READING

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