A cost-benefit analysis of a cardiovascular disease prevention trial, using folate supplementation as an example.

@article{Hornberger1998ACA,
  title={A cost-benefit analysis of a cardiovascular disease prevention trial, using folate supplementation as an example.},
  author={John C. Hornberger},
  journal={American journal of public health},
  year={1998},
  volume={88 1},
  pages={61-7}
}
OBJECTIVES This study illustrates a cost-benefit analysis of clinical trial design, using as an example a trial of folate supplementation to prevent cardiovascular disease. METHODS Bayesian statistical and decision-analytic techniques were used to estimate the cost-benefit and sample size of a placebo-controlled trial of folate targeted to US citizens, aged 35 to 84 years, with elevated serum homocysteine levels. The main end point is event-free survival (i.e., survival without new ischemic… CONTINUE READING

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