A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5.

@article{Kapanadze1998ACA,
  title={A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5.},
  author={Bagrat Kapanadze and Vladimir Kashuba and Anna V Baranova and Omid Rasool and W J van Everdink and Yang Liu and A B Syomov and M. Corcoran and Andrew Poltaraus and V Brodyansky and N Syomova and Andrey Kazakov and Rachel Ibbotson and Anke van den Berg and Rinat Gizatullin and Ludmila Fedorova and Galina Sulimova and Alexander Zelenin and Larry J. Deaven and Hans Lehrach and Dan Grand{\'e}r and C. H. Buys and David Oscier and Eugene R. Zabarovsky and Stefan Einhorn and Nick Yankovsky},
  journal={FEBS letters},
  year={1998},
  volume={426 2},
  pages={266-70}
}
B-cell chronic lymphocytic leukemia (B-CLL) is a human hematological neoplastic disease often associated with the loss of a chromosome 13 region between RB1 gene and locus D13S25. A new tumor suppressor gene (TSG) may be located in the region. A cosmid contig has been constructed between the loci D13S1168 (WI9598) and D13S25 (H2-42), which corresponds to the minimal region shared by B-CLL associated deletions. The contig includes more than 200 LANL and ICRF cosmid clones covering 620 kb. Three… CONTINUE READING

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