A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

@article{Cucca2001ACB,
  title={A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.},
  author={Francesco Cucca and Rosanna Lampis and Mauro Congia and Efisio Angius and Sarah L Nutland and Stephen C. Bain and Anthony Barnett and John A. Todd},
  journal={Human molecular genetics},
  year={2001},
  volume={10 19},
  pages={2025-37}
}
In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and -DR and their murine orthologues, IA and IE, are the major genetic determinants. In this report, we have ranked HLA class II molecule-associated T1D risk in a two-sided gradient from very high to very low. Very low risk corresponded to dominant protection from T1D. We predicted the protein structure of DQ by using the published crystal… CONTINUE READING