A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients.

@article{Kiltie1999ACB,
  title={A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients.},
  author={Anne E Kiltie and Anderson Joseph Ryan and Ric Swindell and John Prentiss Barber and Catharine M L West and Brian A. Magee and Jolyon H. Hendry},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1999},
  volume={51 1},
  pages={
          55-65
        }
}
BACKGROUND AND PURPOSE Prediction of late normal tissue reactions to radiotherapy would permit tailoring of dosage to each patient. Measurement of residual DNA double strand breaks using pulsed field gel electrophoresis (PFGE) shows promise in this field. The aim of this study was to test the predictive potential of PFGE in a group of retrospectively studied breast cancer patients. MATERIALS AND METHODS Thirty nine patients, treated uniformly for breast cancer 9-15 years previously, with… CONTINUE READING
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